James Bond and his beautiful girl Friday, Honey Rider, have been captured by the evil, sadistic Dr No, a sinister recluse with a fascination with pain - other people's pain. Now Dr No holds Bond in his steely grasp, having found him trespassing on his Caribbean island. Intent on protecting his clandestine operations from the British secret service, Dr No sees an opportunity to dispose of an enemy and further his diabolical research. Soon Bond and Rider are fighting to win a murderous game of Dr No's choosing.