The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments. It contains over 30 new figures and tables. It features a new section on new biological concepts relevant to pharmacological research (i.e., systems biology). It presents new study sections organized with ASPET and other international pharmacology organizations and a new coverage of pharmacokinetics and drug disposition.