The use of DNA self-assembly in microchip fabrication may well revolutionize computing, and this trail-blazing book is the first to bridge the gap between current chip technology and the molecular-scale circuitries that lie ahead. It explores the latest breakthroughs in the use of DNA as construction material, and maps out a method for developing DNA self-assembled computer systems that includes detailed design case studies. Probing both the science and the engineering involved, this one-of-a-kind resource reviews current microchip fabrication methods and architectures and discusses fundamentals of nanoscale design and DNA self-assembly. Moreover, the book surveys current limitations and challenges, and features detailed case studies of lightweight self-organizing computer architectures.