Integrated Cardiac Safety

This book covers cardiac safety assessment of drugs at all stages of the lifecycle from discovery thru postmarket research. The focus is on cardiac safety of those drugs that do not target the cardiovascular system, meaning cardiac safety as a possible side effect of drugs. Such safety issues are the leading cause of drug withdrawals from market and failures during development and trial stages. In this self-contained, reader-friendly approach, the author looks at cardiac safety assessments at all stages of a drugs lifecycle including drug discovery, non-clinical research, pre-approval clinical trials, and post marketing research along with guidance and methodology for assessing cardiac safety.