As the Human Genome Project (HGP) reaches its climax, science is fast approaching an exciting new stage in its ability to understand genetic forces in man. In parallel to the HGP are major sequencing efforts in other organisms, enabling us to understand broader questions in evolution and classification. This explosion of data has led to an increased need for sophisticated statistical, mathematical and computational tools to enable complex data collection, analysis and interpretation of the results. This new edition of the well-received best-seller contains nine new articles, including recent developments in gene-expression data analysis. Existing articles have been fully updated, where necessary, and all the references have been updated.