Endocrine Manifestations of Systemic Autoimmune Diseases v9

This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutical management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including the effects on elderly. The perturbations of the HPA axis as source of altered steroidal sythesis will be discussed and related to some interesting pathological conditions often complicating the autoimmune rheumatic diseases susch as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section in Pediatrics.