Drug-Induced Mitochondrial Dysfunction

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. It allows readers to understand the basis of mitochondrial function and the preclinical assessments used and what they reveal about drug effects. The book opens with a discussion of the basic concepts, including mitochondrial physiology, molecular biology, and pharmacogenomics. The following section traces mitochondrial toxicity through specific organ systems liver, heart, skeletal muscle, and kidneys are included. The final section covers in vitro and in vivo assessments, with chapters on screening methods, animal models, and antiviral toxicity.