Rho GTPases in Cancer

The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.Table of ContentsPreface i.Introduction v.Aron Jaffe and Alan HallList of Contributors xix. Section I- An Overview of the Rho GTPasesChapter 1.Overview of Rho GTPase History 1. Ellen V. Stevens and Channing J. DerChapter 2.Rho GTPases and Cancer 43.Devin T. Rosenthal, John Chadwick Brenner, and Sofia D. Merajver Section II- The Rho Regulatory Proteins in CancerChapter 3.RhoGDIs in Cancer 67.Anthony N. Anselmo, Gary M. Bokoch, and Céline DerMardirossianChapter 4.Signaling through Galpha12/13 and RGS-RhoGEFs 93.Nicole Hajicek, Barry Kreutz and Tozu KazasaChapter 5.Vav Proteins In Cancer 126.Daniel D. BilladeauChapter 6.Rho GTPase-Activating Proteins in Cancer 156.Matthew W. Grogg and Yi Zheng Section III- The Rho GTPase Proteins and CancerChapter 7.RhoBTB Proteins in Cancer 182.Caroline McKinnon and Harry MellorChapter 8.RhoC GTPase in Cancer Progression and Metastasis 197.Kenneth L. van GolenChapter 9.RhoB GTPase and Farnesyl Transferase Inhibitors (FTIs) in Cancer 219.Minzhou Huang, Lisa D. Laury-Kleintop and George C. PrendergastChapter 10.Regulation of Rho GTPase Activity Through Phosphorylation Events:A Brief Overview 257.Heather Unger and Kenneth L. van GolenChapter 11.The Rho-Regulated ROCK Kinases in Cancer 273.Grant R. Wickman, Michael Samuel, Pamela A. Lochhead and Michael F. Olson