Peptide and Protein Design for Biopharmaceutical Application

Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include:Computer modeling of peptides and proteinsPeptidomimeticsDesign and synthesis of cyclic peptidesCarbohydrates in peptide and protein designDe novo design of peptides and proteinsMedical development applicationsAn extended case study – the design of insulin variants