For all scientists concerned with the development of new drugs, this standard work is well-known as "the Negwer". The eighth edition of the Negwer once again shows an impressive enlargement: Including more than 3.000 newly developed drugs, it now compiles more than 16.000 chemically unique drugs with more than 125.000 synonyms. The main part of the book (volumes 1-3) consists of the list of organo-chemical drugs arranged by increasing molecular formulas. The following items are given for each of the drugs included: an own consecutive number, the molecular formula, the Chemical Abstracts Service index number (CAS number), the structural formula, references, the synonyms used to identify the drugs (names adopted by certain institutions, common trivial names, names adopted by manufacturers, experimental names, abbreviations; and, marked with asterisks, the non-propietary names proposed by the WHO), characterization and therapeutic use. The indices to facilitate working with the list are assembled in volume 4: a group index (for finding drugs related to each other chemically or pharmacologically), the CAS number index, and the index of synonyms.