Natural Compounds and Their Role in Apoptotic Cell Signaling

Apoptosis is a highly regulated mechanism by which cells undergo cell death in an active way. As one of the most challenging tasks concerning cancer is to induce apoptosis in malignant cells, researchers increasingly focus on natural products to modulate apoptotic signaling pathways. This book reviews the main effects of natural compounds on the different apoptotic signaling pathways, including the intrinsic and extrinsic apoptosis pathways, the NF-kB-mediated pathway, the PI3K/Akt signaling, and other main pathways. Among the topic specially covered are:Effects of natural compounds on cancer cellsNatural compounds as inducers of cell deathDiet in health and diseaseInflammation and cancerNatural compounds as kinase inhibitorsNatural compounds in neurodegenerative diseasesNatural compounds as inhibitors of ROS