Written by renowned specialists in the field, this is a comprehensive and timely overview of a central and expanding topic in immunology and cell biology. At once an introduction and a description of the latest concepts, findings and methods, the handbook provides fundamental knowledge on scientific and technical issues required by those intending to research leukocyte trafficking. It thus covers the functional role of involved molecules and the cellular mechanisms, and addresses elected examples for their possible applications in therapy bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, the book includes a selection of proven methods for studying cell trafficking in vitro and in vivo. The accompanying CD-ROM includes all figures of the book as electronic files and makes keukocyte migration videos available to a wide audience for the first time.