The definitive clinical reference on toxicologic agents, effects, and treatment ' freshly revised and expanded An editorial team of six preeminent clinicians and educators with 135 multidisciplinary contributors A case-based approach to each of 127 chapters in the clinical section In-depth coverage of antidotes Quick-reference tables offering key vital-sign statistics, lab values and common equations Expanded coverage on bio-terrorism, inhalant abuse and international considerations Companion website with six core chapters and their illustrations ' plus a case-based annotated multiple choice Q&A for self-assessmentThe definitive clinical reference on toxicologic agents, effects, and treatment ' freshly revised and expanded An editorial team of six preeminent clinicians and educators with 135 multidisciplinary contributors A case-based approach to each of 127 chapters in the clinical section In-depth coverage of antidotes Quick-reference tables offering key vital-sign statistics, lab values and common equations Expanded coverage on bio-terrorism, inhalant abuse and international considerations Companion website with six core chapters and their illustrations ' plus a case-based annotated multiple choice Q&A for self-assessmentCase based approach-maximizes understanding of clinical applications of material Antidotes in depth- provides quickly accessible, specific, detailed information about antidotes Quick reference tables on inside covers- immediate access to "must have" vital sign statistics, lab values, and common equations New International Considerations- a brief section in pertinent chapters will address this emerging issue of emergency medicine New Increased bioterrorism coverage- expanded coverage of high impact topic for health care providers New Expanded coverage of inhalant abuse- thorough information on growing clinical problem, especially in adolescent patients Logically organized into three major sections to facilitate information access: Part A. The General Approach to Medical Toxicology The first section addresses initial evaluation of patients, management principles and diagnostics: EKG, imaging studies and lab tests. This section advises on how to prevent gastrointestinal absorption or enhance elimination of toxic agents, and when and why to admit to the ICU for monitoring. Part B. The Fundamental Principles of Medical Toxicology This section discusses basic science: biochemical and molecular principles, CNS involvement and withdrawal. Arranged by organ system, the text here concentrates on the pathophysiology of agents toxic to each system. The section closes with chapters on special populations. Part C. The Clinical Basis of Medical Toxicology At the heart of Goldfrankżs new edition is its section on the clinical evaluation and management of patients presenting with poisonings or overdoses. Each of the 127 in-depth chapters is organized in a consistent format, featuring: Case history ż History and epidemiology ż Pharmacology ż Pharmacokinetics ż Toxicokinetics ż Pathophysiology ż Clinical manifestations ż Diagnostic testing ż Management ż Summary NEW to Goldfrankżs Eighth Edition: ż New authoritative advice International authors broaden the scope of many chapters; this new authorship captures the fresh and unique perspectives of these renowned contributors. These include 135 experts who practice and teach in major medical centers across the US, Canada, Europe and Asia. Their specialties include medical toxicology, psychiatry, emergency medicine, pediatrics, internal medicine, surgery, anesthesiology, public health and pharmacy. ż Expanded coverage: Thirty new chapters on international epidemiology, medication errors, adverse events, drug development and risk Five chapters on terrorism preparedness, chemical and biological weaponry and radiation Two chapters on disinfection and infection control Chapter on worldwide epidemiology of toxicology Increased emphasis on improved usage of medications in chapters on patient safety and poison prevention Chapters on public health, potential of medical informatics and the key role of providers in improving care Expanded coverage of inhalant abuse ż a growing problem, especially in adolescents New section on communication Seven chapters on poison centers and epidemiology, including prevention, international perspectives, adverse drug events and medications, errors and patient safety, risk management, legal considerations and more ż In-depth coverage of antidotes Goldfrankżs Eighth Edition features a Table of Antidotes in Depth, a listing of 37 individual and groups of antidotes, along with their corresponding page numbers within the clinical section of the text. Discourse includes an overview followed by: History ż Chemistry ż Pharmacology ż Pharmacokinetics and pharmacodynamics ż Adverse effects ż Use for opioid and ethanol abstinence ż Miscellaneous uses ż Dosing ż Availability ż References. Closing the clinical section are seven chapters on poison centers and epidemiology as well as medico-legal considerations. ż Improved organization Complete restructuring of the textżs Index and comprehensive cross-referencing help you locate the precise information you need instantly ż New Online Learning Center Offers six core chapters with full-color visual images: dermatology, plants, mushrooms, marine envenomations, snakes, and arthropods. The Web site also features a self-study section containing case studies and annotated multiple-choice Q&A for self-assessment