George Beadle was a towering scientific figure whose work from 1940 to 1960 marked the transition from classical genetics to the molecular era. Among other distinctions, he made the pivotal, Nobel prize winning discovery with Edward Tatum that the role of genes is to specify proteins. From 1946 to 1960 he led the Caltech Biology Division, rebuilding it to a powerhouse in molecular biology, and afterwards became a successful President of the University of Chicago. This biography of a giant of genetics is written by two of the field's most distinguished contributors, Paul Berg and Maxine Singer.