This volume focuses on breakthroughs in genetic analysis and manipulation. It details how genetic model systems facilitate better comprehension of mammalian and human biology and disease, and highlights studies of Drosophila melanogaster Caenorhabditis (C.) elegans, zebrafish, and transgenic mouse models - revealing high functional conservation to homologous genes in humans and promoting insight into biological processes. The contributions apply technical and research advances toward the discovery of potential therapeutic gene agents.