Biology & Pathology of Trophoblast

This is the first dedicated, in-depth account of trophoblast: the tissue derived from the fertilized egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is still a lot to be learned about trophoblast: this volume provides an up-to-date summary of the state of current knowledge and offers some glimpses as to future development on the scientific and clinical front. • Covers reproductive immunology, genetics and pathology • Basic science and clinical aspects dealt with in depth • Of interest and relevance to all who study the placenta