Newborn Brain Neuroscience and Clinical Applications

Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child’s future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.• Describes the milestones of brain development in the fetus and the newborn – correlated with neuroimaging studies • Describes in depth all the common disturbances and diseases of the newborn brain – clinical disorders and management highlighted • Describes in detail the main neurological complications seen in preterm infants – relevant to critical care practiceList of contributors; 1. Reflections on the origins of the human brain Jean-Pierre Changeux; Part I. Making of the Brain: 2. The molecular basis of central nervous system development Ola Hermanson and Urban Lendahl; Historical box 1; 3. Holoprosencephaly and microcephaly vera: perturbations of proliferations Verne S. Caviness Jr, Pradeep G. Bhide and Richard S. Nowakowski; Historical box 2; 4. Neuronal migration Sandrine Passemard, Angela M. Kaindl, Virginia Leverche, Pascal Dournaud and Pierre Gressens; 5. Synaptogenesis in the neocortex of the newborn: the ultimate frontier for individuation? Jean-Pierre Bourgeois; 6. Neurotrophic factors in brain development Thomas Ringstedt; Historical box 3; 7. Neurotransmitters and neuromodulators Eric Herlenius and Hugo Lagercrantz; Historical box 4; 8. Glial cell biology Arne Schousboe and Helle S. Waagepetersen; Part II. Sensory Systems and Behavior: 9. Development of the somatosensory system Sandra Rees, David Walker and Ernest Jennings; 10. Principles of endogenous and sensory activity-dependent brain development: the visual system Anna A. Penn and Carla J. Shatz; Historical box 5; 11. Fetal and neonatal development of the auditory system S. Allen Counter; 12. Newborn behaviour and perception Elena V. Kushnerenko and Mark H. Johnson; Part III. Radiological and Neurophysiological Investigation: 13. Imaging the infant brain Mary A. Rutherford; 14. Electroencephalography and amplitude-integrated EEG Lena Hellström-Westas and Ingemar Rosén; 15. Emergence of spontaneous and evoked EEG activity in the human brain Sampsa Vanhatalo and Kai Kaila; Part IV. Clinical Aspects: 16. Perinatal infections and brain injuries Donald Peebles; 17. Hypoxic-ischemic encephalopathy Deanna L. Taylor, Grisha Pirianov, A. David Edwards and Henrik Hagberg; 18. Clinical assessment and therapeutic interventions for hypoxic-ischemic encephalopathy in the full-term infant Andrew Whitelaw and Marianne Thoresen; 19. Clinical aspects of brain injury in the preterm infant Michael Weindling; Part V. Follow-Up: 20. Injury and recovery in the developing brain Koray Özduman and Laura R. Ment; 21. Development of motor functions in health and disease Mijna Hadders-Algra and Hans Forssberg; 22. Antenatal glucocorticoids and programming of neuroendocrine function and behavior Stephen G. Matthews and Amita Kapoor; Part VI. Consciousness: 23. On the emergence of consciousness Hugo Lagercrantz and Jean-Pierre Changeux; Index.