Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: * Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. * Two chapters on tauopathies under new authorship. * A chapter under new authorship on synucleinopathies, which includes multiple system atrophy. From reviews of the first edition: 'This up-to-date and authoritative account will be invaluable for practising neuropathologists and a treasured work of reference for psychiatrists and neuroscientists with an interest in dementia.' Nigel J. Cairns, International Journal of Geriatric Psychiatry ' ... this publication is a 'must have' for every practising neuropathologist.' Journal of Neuropathology and Experimental Neurology* Completely rewritten and updated new edition of a highly successful book * International team of top-notch experts covering comprehensively all aspects of the neuropathology of dementia * Gives practical guidance for practising pathologistsFrom reviews of the first edition: 'This up-to-date and authoritative account will be invaluable for practising neuropathologists and a treasured work of reference for psychiatrists and neuroscientists with an interest in dementia.' Nigel J. Cairns, International Journal of Geriatric Psychiatry'It should undoubtedly be on the shelves of consultant histopathologists in a teaching hospital ... I am delighted to have a copy and have already consulted it with more enthusiasm than I would have believed possible.' Jennian F. Geddes, Journal of the Royal Society of Medicine'... this is certainly a compulsory purchase for neuroscience centres. It deserves to live on into further editions whose evolution will map the rapid advances being made in many of the conditions covered within.' P. G. Ince, Neuroradiology'The authors are to be congratulated on successfully producing a book that is well written, undoubtedly of practical use to pathologists and neuropathologists, yet contains a wealth of information for clinicians and researchers. It will be an essential reference for all laboratories and departments which make use of post-mortem diagnosis (whether for clinical or research purposes) and all old-age psychiatrists involved in dementia research will want access to a copy.' John O' Brien, The British Journal of Psychiatry