Computational Protein Protein Interactions (WYSYŁKA KURIEREM GRATIS!)

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current research directions, Computational Protein-Protein Interactions examines topics in the prediction of protein-protein interactions, including interference with protein-protein interactions and their design. * Provides an overview of the basic principles of protein-protein interactions and the biophysical forces driving them
* Investigates the architecture of binding sites, providing a detailed molecular description of their composition and describing how this drives binding
* Includes a summary of the pathway for protein-protein interactions
* Presents examples of successes and failures that demonstrate the current state of research, the main problems, and what to expect in the future
* Explores how to use structural information to map function as embedded in the subcellular structural organization of the proteins
* Describes the mechanisms by which domain rearrangements occur in the genome and highlights the role of co-occurring domains in protein-protein interactions