Over the past three to five years biosecurity has become a more commonly used word, first with veterinary professionals and then more recently with the media that serve the agriculture community. The speculation about the potential of intentional introduction of disease agents has raised the concern level about this issue even higher. The authors of this issue hope to provide the veterinary practitioner with a framework for developing and customizing biosecurity programs directed at controlling certain types of infectious disease agents. The information in the following chapters will provide a framework for developing biosecurity and biocontainment programs for cattle operations and veterinary clinics.