Developed nations are experiencing enormous increases in the number of elderly people in the population. Ageing is a universal complex multifaceted process that profoundly affects mind and brain of all individuals. Important discoveries are being made at different levels of research on cognitive aging: from the molecular/genetic level, to the cell, the network, and the processing of information at the cognitive level. The aim of this special issue is to examine new breakthroughs of the aging mind and brain and how to use this knowledge to promote interdisciplinary research in normal and pathological aging.